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John Q Trojanowski Selected Research

Neoplasms (Cancer)

1/2020Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease.
9/2014Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease.
8/2012Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies.
10/2010Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.
8/2003Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas.

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John Q Trojanowski Research Topics

Disease

289Alzheimer Disease (Alzheimer's Disease)
03/2024 - 06/2002
122Neurodegenerative Diseases (Neurodegenerative Disease)
03/2024 - 05/2002
109Parkinson Disease (Parkinson's Disease)
03/2024 - 02/2002
99Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
05/2023 - 05/2005
97Cognitive Dysfunction
01/2023 - 01/2002
84Dementia (Dementias)
11/2023 - 06/2002
79Tauopathies
03/2024 - 05/2002
74Frontotemporal Dementia (Semantic Dementia)
02/2023 - 05/2003
53Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
10/2021 - 11/2004
52Synucleinopathies
03/2024 - 05/2002
47Atrophy
11/2023 - 11/2003
34Amyloid Plaque
01/2022 - 11/2002
26Disease Progression
11/2022 - 02/2004
15Amyloidosis
01/2020 - 07/2002
15Motor Neuron Disease (Primary Lateral Sclerosis)
01/2019 - 09/2004
14Proteostasis Deficiencies
11/2023 - 11/2011
13Corticobasal Degeneration
11/2019 - 06/2002
13Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
01/2019 - 05/2005
13TDP-43 Proteinopathies
01/2018 - 07/2007
12Traumatic Brain Injuries (Traumatic Brain Injury)
01/2023 - 01/2003
12Multiple System Atrophy
10/2022 - 12/2002
10Parkinsonian Disorders (Parkinsonism)
10/2022 - 11/2003
9Pick Disease of the Brain (Pick's Disease)
01/2021 - 06/2002
8Lewy Body Disease (Lewy Body Dementia)
10/2023 - 07/2011
8Inflammation (Inflammations)
01/2022 - 03/2004
7Gliosis
11/2023 - 12/2002
7Movement Disorders (Movement Disorder)
01/2019 - 05/2002
6Cerebrovascular Disorders (Cerebrovascular Occlusion)
01/2020 - 09/2013
6Hippocampal Sclerosis
09/2014 - 12/2011
5Neuroinflammatory Diseases
01/2020 - 02/2007
5Neoplasms (Cancer)
01/2020 - 08/2003
5Wounds and Injuries (Trauma)
06/2014 - 08/2004
4Sarcoma (Soft Tissue Sarcoma)
02/2023 - 07/2010
4Tremor (Tremors)
01/2022 - 05/2006
4Memory Disorders (Memory Loss)
06/2021 - 04/2005
4Down Syndrome (Down's Syndrome)
01/2020 - 11/2002
4Brain Injuries (Brain Injury)
11/2015 - 08/2004
4Central Nervous System Diseases (CNS Diseases)
09/2014 - 05/2002
3Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder)
06/2022 - 06/2014
3limbic-predominant age-related TDP-43 encephalopathy
01/2022 - 01/2019
3Brain Diseases (Brain Disorder)
01/2022 - 04/2013

Drug/Important Bio-Agent (IBA)

181Biomarkers (Surrogate Marker)IBA
11/2023 - 07/2003
118Amyloid (Amyloid Fibrils)IBA
11/2023 - 11/2002
117Proteins (Proteins, Gene)FDA Link
03/2024 - 02/2002
63DNA-Binding Proteins (DNA Binding Protein)IBA
02/2023 - 07/2007
55alpha-SynucleinIBA
03/2024 - 02/2002
52SynucleinsIBA
11/2023 - 05/2002
48Amyloid beta-PeptidesIBA
03/2024 - 05/2002
46tau Proteins (tau Protein)IBA
10/2021 - 06/2002
36Apolipoproteins E (ApoE)IBA
01/2023 - 03/2010
27UbiquitinIBA
02/2023 - 12/2002
22Peptides (Polypeptides)IBA
01/2020 - 12/2002
18ApolipoproteinsIBA
12/2022 - 10/2006
18ProgranulinsIBA
12/2018 - 03/2007
16AntibodiesIBA
02/2023 - 06/2002
14Protein Isoforms (Isoforms)IBA
05/2023 - 06/2002
14DNA (Deoxyribonucleic Acid)IBA
12/2021 - 10/2003
13Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
03/2024 - 11/2004
11Phosphotransferases (Kinase)IBA
01/2021 - 12/2005
10florbetapirIBA
10/2020 - 01/2013
10Carrier Proteins (Binding Protein)IBA
12/2019 - 01/2005
9EnzymesIBA
10/2019 - 12/2002
8Threonine (L-Threonine)FDA Link
01/2023 - 04/2009
8Monoclonal AntibodiesIBA
11/2020 - 11/2003
8Excipients (Suspending Agents)IBA
09/2017 - 08/2012
7Leucine (L-Leucine)FDA Link
01/2021 - 02/2006
7Protein AggregatesIBA
04/2015 - 01/2004
6RNA-Binding Proteins (RNA-Binding Protein)IBA
03/2024 - 05/2008
6PrionsIBA
01/2022 - 05/2012
6Apolipoprotein E4IBA
10/2020 - 05/2005
6Glucose (Dextrose)FDA LinkGeneric
01/2019 - 10/2011
62- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA
10/2015 - 05/2010
5LipidsIBA
05/2023 - 01/2019
5thioflavin TIBA
11/2019 - 04/2005
5Dopamine (Intropin)FDA LinkGeneric
11/2017 - 06/2005
5Complement System Proteins (Complement)IBA
01/2017 - 05/2003
5amyloid beta-protein (1-42)IBA
02/2015 - 04/2009
5Valosin Containing ProteinIBA
12/2010 - 07/2007
5IsoprostanesIBA
08/2010 - 01/2002
4Glucosylceramidase (Glucocerebrosidase)IBA
05/2023 - 06/2013
4NeurograninIBA
01/2023 - 11/2015
4CholesterolIBA
12/2022 - 10/2005
4LigandsIBA
01/2020 - 09/2013
4Messenger RNA (mRNA)IBA
12/2019 - 07/2002
4ImmunosorbentsIBA
10/2019 - 09/2011
4desoxyepothilone B (epothilone D)IBA
09/2016 - 10/2010
4Amino AcidsFDA Link
12/2015 - 12/2010
4polyglutamineIBA
11/2015 - 01/2004
4Blood Proteins (Serum Proteins)IBA
10/2015 - 08/2012
4Paclitaxel (Taxol)FDA LinkGeneric
04/2011 - 07/2007
3beta-SynucleinIBA
01/2023 - 08/2003
3Apolipoprotein A-I (Apolipoprotein A1)IBA
12/2022 - 07/2013
3IronIBA
01/2022 - 05/2006
3RNA (Ribonucleic Acid)IBA
01/2021 - 03/2014
3Prion ProteinsIBA
11/2020 - 04/2013

Therapy/Procedure

43Therapeutics
09/2023 - 04/2002
8Injections
11/2020 - 02/2015
5Immunotherapy
01/2021 - 01/2015
4Transplantation
05/2008 - 04/2003
3Activities of Daily Living (ADL)
01/2021 - 04/2016